Introduction: Prostate
cancer (PCa) is one of the leading causes of death in men’s population
worldwide. Various clinical samples such as urine, blood serum and prostatic
fluid have been commonly used for the identification of PCa-associated
molecular changes. Tissue, being the site of disease genesis, is increasingly
gaining more attention as a study material, aiming at the discovery of
biomarkers for predicting the disease outcome and therapeutic targets.

Areas covered: The
current review is the output of a systematic literature search on Pubmed to
retrieve articles relevant to the proteomic analysis of tissues for the study
of prostate cancer. Studies performed the last 10 years using human tissues are
summarized.

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Expert commentary: Multiple
proteomics studies were performed the past 10 years focusing on PCa initial
diagnosis and staging. Even though some reproducible findings have been
reported, many studies lacked adequate validation of findings and relied on
relatively lower resolution proteomics techniques in comparison to current
state of the art. Incorporation of high resolution proteomics techniques
(including investigations at protein PTMs) is expected in the near future to
complement other –omics and enhance current efforts towards molecular subtyping
of PCa for patient stratification.

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