NEW its expenses. There several antibiotics like glycylcycline

NEW
TREATMENT APPROACHES AND THERAPEUTIC ALTERNATIVES

In
the recent time it has been said that MRSA infections in the western
countries like America has increased and mortality rate is increased
than the AIDS. Life threatening diseases are caused by toxins from
CA-MRSA strain like Panton- Valentine Leukocidin (PVL) and
Phenol-Soluble Modulins (PSM)25. About three half of the infection
affects skin and soft tissues in the body. There are several drugs
which were introduced into the action and were got resisted. There
are some conditions to be fulfilled for getting an effective
antibiotic like antibiotic target must exist inside the bacterial
cell, effective amount of antibiotic must be reached in targeted
site, the antibiotic should not get metabolized. Introduction of
third generation cephalosporins shows a wide coverage using a single
therapeutic agent. Number of studies has shown that monotherapy is
better than combination therapy Daptomycin, a cyclic lipopeptide
antibiotic was used to treat both CA-MRSA and HA-MRSA. It acts by
disrupting the bacterial cell wall leading to its lysis. It was
accepted due to its safe line but it got inactivated by pulmonary
surfactants. Vancomycin was used to overcome the infection. It was
selected due to its safe profile and insufficient active drug. Use of
this was stopped due to the evolution of Vancomycin Intermediate
Resistant Staphylococcus Aureus (VISA). Chemotherapy using linezolid
was limited due to its expenses. There several antibiotics like
glycylcycline antibiotic, cephalosporins (due to its affinity on
PBPs) were used25. There are several researches undergoing to
develop new drugs with a novel action against MRSA. Development of
novel drugs should be able to overcome the resistance offered and its
actions should involve shortening the therapy schedule, harmful
effects should be reduced or eradicated, moreover the resistance
should be eradicated and the combination therapies must have
excellent efficacy. Contemporary details of the research can be sited
in several web sites. Some of the recent studies in MRSA had came out
and several industries are working to get a result. Some of the
studies and inventions of different companies are mentioned below
:CONCLUSION
The
era of antibiotic dominance has been coming to extinct after the
brunt of bacteria against antibacterials. Growing infections are
impossible to treat and leads to severe health care risks. WHO
mentioned that newly discovered agents are not effective against
highly resistant bacteria. Most of the phyto constituents are having
effective antibacterial effect but the technique of isolation and
search should be systematically done to get a proper effective
antibiotic with safer margin of action. Since the present antibiotics
are resisted in action, novelty of new antimicrobial must overcome
it.

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